Trish's in-ring career was winding down by the time WrestleMania 22 approached. A back injury had sidelined her throughout a good portion of 2005, but by the time she returned in the fall, she was in top form and had returned to her role as babyface after a year as a the most vile villain on the Divas roster.
Her first rivalry, with Ashley Massaro as her partner, was against the trio of Torrie Wilson, Candice Michelle and Victoria. In an attempt to even the sides, the company called up Mickie James from developmental. Her character would be that of an obsessed Trish fan who would do anything for her idol.
Unfortunately, her love and devotion was not returned, and Mickie became more and more unstable as the weeks passed. Eventually, she snapped and became a heel. The destruction of Trish Stratus became the obsession of Mickie, with the Women's Championship being the cherry on the sundae.
The crowd in Chicago was behind Mickie, but the consummate pro in Trish refused to let the vocal fans get in her head.
Trish and Mickie told a tremendous story and the match built around it. Mickie targeted the knee, taking away the Women's champion's base. Every time it appeared as though Trish was about to make a comeback, Mickie would go back to that knee. When that did not work, she reverted to mind games.
Late in the match, Trish grabbed a side headlock and appeared poised to put Mickie away with the Stratusfaction Bulldog. In a shocking moment, Mickie grabbed Trish between the legs. The shock of the situation gave Mickie a moment to escape a floored Trish. Mickie would then attempt a Stratusfaction of her own, but Trish's knee would give out. A Chick Kick from the challenger would be all she would need. Three seconds later, Mickie captured her first Women's Championship to the delight of the Chicago fans.
The match was one of Trish's last truly great ones and one that was befitting of the stage that WrestleMania presents. On that night, April 2, 2006, she passed the torch to one of the women the company would rely on to carry the Divas division in the years that followed.
Even in a loss, Trish's understated performance at the "Showcase of the Immortals" remains one of her best and, at the same time, one of her most under-appreciated.