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Without a doubt, this will be the match that almost every casual fan will watch on Monday. It's a game between two of England's richest clubs, with bragging rights on the line for the fans in attendance.
However, the result of this match won't define which team wins the Premier League title—that's already been decided. At this point, it's not a matter of if, but when United are crowned champions.
They haven't lost in the league since November, and they've only dropped points to Swansea and Tottenham since. Even then, Swansea and Tottenham only picked up a point each.
Robin van Persie (pictured) scored the winner the last time these two titans went up against each other, and although the Dutchman is without a goal in his last nine games, he's one to watch on Monday.
If United win this match—and their form since Nov. 17 suggests they will—then they go 18 points clear of City. Even if they don't and City either win or draw the match, City would still need United to drop more points in their last six games than they have for almost the entire season.
I just don't see it happening.
Yes, City have been decent of late, winning three of their last four league games, but it's not going to be enough.
For a variety of reasons, Roberto Mancini's biggest players haven't performed this season. Carlos Tevez and David Silva have been inconsistent, and injuries have hindered Sergio Aguero and Vincent Kompany at key points during the year.
Edin Dzeko and Yaya Toure have done well, but two players can't pull a team through.
Samir Nasri might have had an excellent game in City's 4-0 win over Newcastle last week, but more often than not, the Frenchman fails to deliver. He's clearly talented, but sometimes when you watch him, it doesn't look like he wants it enough.
It wouldn't surprise me in the slightest if Nasri doesn't start the game on Monday. Mancini may choose to go with solid rather than spectacular players to try to keep United at bay, then hit them on the counterattack.
The form book points to a United win here, but then again, City winning wouldn't be a shock given the tension between these two clubs.
Prediction: Manchester United win