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With many of Manchester United's most prominent players engaged in international action over the long weekend, it is difficult to predict Sir Alex Ferguson's starting lineup.
Whether he fields his strongest possible lineup or opts for rotation, he will not underestimate his opponents.
Ryan Giggs could see himself in the starting XI, as could Rio Ferdinand, who controversially withdrew from the England setup last week.
With Lee Cattermole and Steven Fletcher ruled out for the rest of the season, Martin O'Neill has a slight selection dilemma for Saturday's clash.
Former Swansea City forward Danny Graham could be asked to lead the line, while youngster Connor Wickham could also be in contention for a place in the starting lineup.
Sunderland: Simon Mignolet, John O'Shea, Carlos Cuellar, Danny Rose, Craig Gardner, Sebastian Larsson, James McClean, Adam Johnson, Stephane Sessegnon, Danny Graham, Connor Wickham.
Manchester United: David de Gea, Rafael, Nemanja Vidic, Rio Ferdinand, Patrice Evra, Michael Carrick, Ryan Giggs, Ashley Young, Shinji Kagawa, Wayne Rooney, Robin van Persie.