The Premier League is back this weekend after a 10-day break for the latest set of World Cup qualifiers.
There's a lot to play for at both ends of the table as the fight for Champions League places and the fight to avoid relegation from the Premier League enter the final set of hurdles.
During the international break, Wayne Rooney scored twice for England, and he'll want to take that form with him as Manchester United look to increase their lead at the top of the table.
This week's six key battles will primarily look at the sides scrapping for Premier League survival, so without any further ado, let's take a look at them!
As usual, my predictions will be at the bottom of each slide.
The first of Saturday's games to watch comes from the Stadium of Light, where Sunderland host league leaders Manchester United.
BBC Sport reported on Wednesday that Steven Fletcher is likely to be out for the remainder of the season after being injured on international duty with Scotland.
The striker will be a huge miss for the Black Cats.
You could argue that, without Fletcher's goals, Sunderland would be in worse trouble than they are already.
He's scored 11 times already this season, which accounts for a third of Sunderland's entire goal tally.
It's time for others to step up in Fletcher's absence, so now could be the time for Danny Graham to lead the line.
You'd have to expect him to start against Manchester United on Saturday.
After United's win against Reading almost two weeks ago, Sir Alex Ferguson issued a stark warning to anyone suggesting his team might slip up in the final few weeks of the season.
Speaking to BBC Sport after the game, Sir Alex said:
You don't get points or medals for being complacent and we won't be... Most of the time, we have been playing well this season, but the 15 points we are ahead isn't a reflection of the performance today, it's from the previous six months really.
It's hard to argue with Sir Alex's assessment of things.
Their win against Reading was uninspiring at times, but they still managed to win the game and keep a clean sheet.
Saturday's game at Sunderland will probably be more of the same.
United might not be at their best, but they should still have enough to win the game.
If they do that, they'll increase their lead at the top of the table to 18 points, for a few hours at least, and plunge Sunderland deep into relegation trouble.
Manchester United win
Arsenal host Reading on Saturday in a game that's important for both clubs.
Arsenal need to win to stay in the race for a place in next season's Champions League, and Reading need to take something from the game to give themselves a chance of Premier League survival.
Now that they've been eliminated from the Champions League, Arsenal's main focus is on finishing in the top four.
In terms of their current league form, they've won four of their last five games, which is excellent.
However, Theo Walcott is a doubt for the game after picking up an injury during an England training session last week.
If Walcott doesn't make it, Arsenal should have enough quality to see off Reading.
The visitors on Saturday have appointed former Southampton boss Nigel Adkins as their new manager.
In my opinion, he was harshly dealt with at Southampton.
Before Southampton sacked him, he was picking up some decent results after a poor start to the season, so on a personal note, it's good to see Adkins back in the game.
He couldn't have asked for a tougher start to life in his new job.
He'll take his new side to Arsenal on Saturday in hope, more than expectation, of picking up a positive result.
Reading will make it tough for the Gunners, but Arsenal will have enough about them to win the match.
Both of these sides lost their last Premier League matches.
Manchester City lost 2-0 to 10-man Everton, while Newcastle lost 2-1 to Wigan.
Roberto Mancini hasn't been able to call upon the services of Vincent Kompany or Sergio Aguero in recent weeks because of injury.
But the Italian feels that they should be fit for Saturday's match with Newcastle.
If City fail to win on Saturday, they will slip even further behind Manchester United before City travel to Old Trafford on April 8.
That's something that the City board, management team, players and fans won't want to happen.
Newcastle's loss to Wigan was somewhat marred and overshadowed by a horrific tackle on Massadio Haidara.
Although it's since been confirmed that the defender wasn't seriously injured, it was still an awful challenge, and it's good that he'll be back playing again soon.
This is a big couple of weeks for Newcastle.
After this game with City, they have to play both legs of their Europa League quarter-final against Benfica, as well as having a Premier League clash against Fulham sandwiched between them.
Winning the Europa League would be a massive accomplishment, but surely it shouldn't come at the expense of Premier League survival.
Newcastle have the potential to cause City problems, but the current Premier League champions should pick up a hard-earned victory here.
Manchester City win
Wigan host Norwich on Saturday afternoon in yet another game that has huge implications for both teams.
After all the furore over Callum McManaman's horror tackle on Massadio Haidara in their last match, you'd be forgiven for forgetting that Wigan actually won the game 2-1.
Yes, the tackle had an influence on the game, but to me, it seemed more mistimed than malicious.
Arouna Kone scored a last-minute winner to secure all three points for his side.
He's scored in some important games lately, against Reading and Newcastle, and he'll need to be watched carefully.
Wigan might have won the match, but they still find themselves in the bottom three.
However, they have a game in hand on their rivals down at the bottom.
On their day, Wigan have the potential to beat anyone.
We all saw that towards the end of last season, so they won't fear Norwich on Saturday.
Last weekend, Norwich announced a major coup with the signing of striker Ricky Van Wolfswinkel from Sporting Lisbon.
The Dutchman won't officially join the club until July 1, but his signing has to be taken as a major statement of intent from Norwich.
Back to matters at hand, though, and Norwich defender Russell Martin thinks his side need two wins to secure their Premier League survival.
They're in 12th position right now with 34 points.
Two wins would take them to that magical 40-point mark, traditionally seen as enough to secure Premier League football for another season.
This game will be good to watch, with plenty of decent football from both sides, but neither side will walk away with a win.
The only Premier League fixture on Sunday comes from Villa Park, where Aston Villa play host to Liverpool.
Paul Lambert's team have picked up some brilliant results lately.
Results that, to be honest, I didn't think they'd get.
However, they went to Reading and won.
They welcomed QPR to Villa Park in their last league outing and won a frenetic, end-to-end game 3-2.
Andreas Weimann scored the goal that turned the game in Villa's favour to make the score 2-1, before a late goal from Christian Benteke secured all three points for Villa.
Weimann has played exceptionally well this season, scoring 11 goals, and he's definitely someone who will play a huge part for Villa in the closing weeks of the season.
Villa have already beaten Liverpool 3-1 this season, so Brendan Rodgers will be fully aware of what to expect on Sunday.
Inconsistency has blighted Liverpool's season.
After beating Wigan 4-0 and Tottenham 3-2 in consecutive weeks, they travelled to Southampton last time out and lost 3-1.
The scoreline didn't flatter Southampton.
Liverpool were second best throughout and deserved to lose the game.
That defeat has all but ended Liverpool's faint hopes of playing in Europe next season, but Brendan Rodgers will want a response from his players.
In terms of the result, it seems to me that Villa have a lot of momentum right now, and they should stay up if they beat Liverpool.
My feeling is that Villa won't lose, but they won't win either.
The final Premier League fixture of the weekend sees Fulham take on QPR.
This match must be the 3,424th London derby of the season.
OK, so it hasn't been, but you get my drift!
Fulham probably had the surprise result of the last round of Premier League fixtures when they beat Tottenham 1-0 at White Hart Lane.
Dimitar Berbatov returned to haunt his old club by scoring the winning goal to earn Fulham all three points.
The Bulgarian's class, touch, ability and vision sets him apart from his teammates at times, and he is so important to Fulham, despite the fact he's only been there for less than a year!
If QPR are to have any chance on Monday night, they need to keep Berbatov quiet.
Harry Redknapp's side lost an enthralling encounter 3-2 against Aston Villa last time out, and QPR now need a miracle to survive.
Even if they win five of their last eight games, which is what Harry Redknapp has targeted, it might not be enough for QPR to survive.
QPR do have some good players, like Ji-Sung Park, Adel Taarabt and Loic Remy, but it's been their loan stars who have shone in the last couple of games.
Jermaine Jenas and Andros Townsend have scored twice in their last two games, and they'll need to keep producing the goods to give QPR a chance.
QPR need to win more games in their last eight matches than they have all season.
It's just too much to ask at this stage of the season.
Both sides will play some decent stuff, but neither side will win.