Of the eight forthcoming Sweet 16 matchups, the Midwest Region possesses the most intriguing of them all as the No. 2 seed Duke Blue Devils will meet the No. 3 seed Michigan State Spartans. Coincidentally, both schools will be returning to the location of their last championship—Duke's fourth, Michigan State's first—Indianapolis, Ind.
Concluding the revealing of the tournament bracket, fans and experts alike envisioned a potential clash between two of the best programs in the country. As Duke and Michigan State easily turned back challenges from their second- and third-round opponents respectably, those pre-tournament predictions will become a realization.
For Duke, the game against Michigan State will be its most challenging of the season. The Spartans are an extremely well-coached basketball team, with a tenacious style of play coupled with superb talent at each position.
In order for the Blue Devils to end the Spartans championship aspirations and keep their own alive, here are the five most important keys to the game that they must follow.