It was only the first full slate of games at the 2013 NCAA tournament, but already, there are a few potential title contenders heading home empty-handed, breaking the hearts and busting the brackets of many basketball fans in the process.
Yes, so far all the No. 1 and No. 2 seeds escaped upsets on Thursday.
But one No. 3 seed needed a frantic comeback in the final minute of play to squeak out a win over Davidson, and others weren't so lucky.
Oklahoma State, New Mexico and UNLV are all out, which means there are a handful of Cinderella squads remaining, but how far can they go?
If recent history is any indication, we have no idea. But that doesn't mean there isn't reason to believe that there won't be a high seed making an appearance in Sweet Sixteen, or even the Elite Eight.
Here's an early look at some of the high seeds that look poised to make deep runs in March.
With all due respect to Harvard's stunner against New Mexico in the round of 64, No. 12 Oregon's upset of No. 5 Oklahoma State was the day's most compelling upset.
Not because the Ducks' opponent was anywhere close to as impressive as Harvard's, but rather, it's because Oregon dominated the Cowboys from the opening tipoff, while the Crimson benefited greatly from New Mexico having a downright awful shooting day.
Going forward, the Ducks' balanced attack, led by Dominic Artis and Damyean Dotson, will have to shoot better in the next round against Saint Louis if the Ducks' surprising run is to continue.
Like the Ducks, Ole Miss also took down a No. 5 seed and a solid one at that in the Wisconsin Badgers.
And it wasn't close.
On Friday, the Rebels came out with fury, and despite Marshall Henderson's mediocre shooting, the star junior managed to lead Ole Miss with 19 points en route to a 57-46 victory over one of the Big Ten's best teams.
Looking ahead, assuming Kansas State waltzes through its opening game against No. 13 La Salle, the Rebels will have their hands full against a Wildcats team that has notched wins against some of the nation's elite.
However, if the Rebels' offense is firing on all cylinders, Ole Miss has the weapons to pull off another major upset and secure a spot in the Sweet Sixteen.
Though California stumbled toward the end of the season, there's no doubting the Golden Bears' ability to rise to the occasion when facing elite teams.
That's what the team showed against UNLV on Thursday, as Allen Crabbe and Robert Thurman led No. 12 Cal into the round of 32 to take on Syracuse.
Heading into the game against UNLV, the Golden Bears had won their last three games against ranked opponents, as they've taken down Oregon twice and then-No. 7 Arizona so far this season.
Cal has not played a team as talented as Syracuse yet, but it wouldn't be the first time a high-seeded Orange team fell earlier than expected.