The Irish hope to erase the memory of last year's early exit.
March Madness continues tonight with a West Regional matchup between the No. 7 Notre Dame Fighting Irish (25-9) and the No. 10 Iowa State Cyclones (22-11).
This is one of the most highly-anticipated matches of the fist round with both teams coming in evenly matched for a game that could legitimately go either way.
The Irish, who have made four straight tournament appearances, hope this year's second round will be kinder than last year when they were bounced by the Xavier Musketeers.
Iowa State on the other hand comes into the tournament hoping to prove they belong after spending the weeks leading up to the unveiling of the brackets firmly on the bubble.
The Cyclones are a gritty bunch who held regular season wins over Oklahoma and Oklahoma State and narrowly lost to Kansas twice.
Neither of these teams will be an easy out and both have much to prove.
Tip-off is scheduled for 9:45 PM EST. Stick with us here for all your live scores, updates and analysis.