Ultimately, when it quickly became apparent that the team selection on the day was not working, Liverpool needed to get some indication from the sidelines that there was a plan in motion to fix things.
A switch to send Coutinho central and Suarez left worked in part; Liverpool retained possession a little better centrally, and Suarez found more space down the channels to be involved in buildup play. Coutinho even scored on the stroke of half time as he was able to be in a more advanced central role.
But the half-time switch of Lucas for Allen, though necessary, did nothing to change the flow of the match.
Southampton were already going to back off more, at least in part to protect their lead, but Liverpool were able to offer nothing new or extra to give themselves more of an effect in the middle and final thirds.
With Jordan Henderson, Suso and would-be-debutant Jordan Ibe on the bench, there were options for Brendan Rodgers to change things around, but the second and final substitute didn't enter the pitch until the final eight minutes of the game, with Liverpool by then 3-1 down.
It wasn't enough from Liverpool, from the players or the management.
Lessons have to be learnt by all parties from this game, and quickly.