Liverpool hope to continue their charge toward a European spot by picking up all three points against a struggling Southampton side. The Reds are currently two points behind Arsenal for a spot in next season's Europa League.
On the flip side, the Saints are fighting to avoid a relegation battle. They are currently four points clear of the bottom three, which is always a good mark since it's greater than the result of one match, but they need to end their current skid to maintain that edge.
Let's take a glance at all the key viewing information for the match, followed by a preview and prediction for a clash that features two clubs desperate for points for different reasons.
Where: St. Mary's Stadium in Southampton, England
When: Saturday, March 16 at 11 a.m. ET
Watch: Fox Soccer Plus
Live Stream: Fox Soccer 2Go
Liverpool have won four straight matches, and in convincing fashion. The hot streak includes a 3-1 victory over Zenit St. Petersburg, which was impressive even though it wasn't enough to complete the aggregate comeback, and a triumph over rival Tottenham.
All told, the Reds have scored 15 goals over the past four matches. That's the biggest difference from earlier in the campaign when they were struggling. They now have enough scoring depth behind Luis Suarez to put up some big numbers instead of relying so heavily on him.
One player that's stepped up in recent weeks has been Stewart Downing. Not only does he have goals in each of his last two appearances, but he's been far more involved in the attack, giving the Reds another option moving forward.
As long as Liverpool continues to play on the level it did last week against Tottenham, this is a match they should win. Even though it's on the road, they can't afford to drop points against a club of Southampton's caliber at this point in the season.
The Saints have gone into a slide since their shocking upset of Manchester City. They dropped three straight matches, including a home loss to the last-place Queens Park Rangers, which makes the win over City even more surprising.
Rickie Lambert has been the club's most dangerous attacking option throughout the season. He's scored just twice over his last seven matches, though. When he's not making plays and putting pressure on the opposing back line, Southampton struggles to create chances.
They also rank in the bottom five in goals allowed, which is an ominous sign ahead of a clash with an offense going as well as Liverpool's is right now. The Reds should be able to take firm control of the match early and cruise to another win.
Prediction: Liverpool 3, Southampton 1