Nani's dismissal cost Sir Alex Ferguson and his team a place in the quarterfinals of the tournament, and it remained a hot topic for the remainder of the week.
However, the other big talking point of the last-16 second leg was the omission of striker Wayne Rooney from the United starting XI.
Rooney's absence for the biggest match of United's season sparked a wave of speculation that the 27-year-old would be leaving Old Trafford in the summer.
However, that has not stopped various media outlets lining Rooney up with other clubs.
Here, we look at the destinations mentioned in the same breath this week as the former Everton forward.
Rooney would link up with some major names at PSG.
PSG were also linked with a multimillion move for Rooney last summer, as The Metro reported.
However, the Daily Mail cautioned against the transfer happening due to taxation issues for high-earning players in France.
Lionel Messi expressed his admiration for Rooney this week.
As the Catalan giants proved with their remarkable Champions League comeback against AC Milan on Tuesday, they remain, arguably, the best team in the world at the moment.
Rooney is no stranger to facing Barcelona after playing for United in two losing Champions League finals against them.
Rooney was carried from the field during his most recent appearance against Bayern Munich in 2010.
But even the Bayern legend did not know whether the speculation linking the forward with the Allianz Arena was true or not.
Incoming Bayern coach Pep Guardiola has previously expressed his views on Rooney (The Sun via ESPN) and has been linked with a move for the striker this summer, according to a report in the Sunday Times (via the Daily Mail).
Claudio Ranieri is now in charge at AS Monaco.
Former Chelsea manager Claudio Ranieri is now in charge at the club and Russian billionaire owner Dmitry Rybolovlev views Rooney as Monaco's marquee signing this summer, according to the report.
The Star article also claims Monaco, who are expected to be promoted from Ligue 2 this year, will offer the 27-year-old a tax-free deal to leave Old Trafford for the Principality.
Rooney scored at the Etihad Stadium earlier this season.
Rooney chose to stay on at United and Mancini maintains he can see no way the forward can leave the club.