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Dani Alves will be a key factor for Barcelona.
Goalkeeper: Victor Valdes
Defense: Dani Alves, Gerard Pique, Carles Puyol, Adriano
Starting goalkeeper Victor Valdes was handed a four-match league ban for his actions towards referee Miguel Perez Lasa after the Copa del Rey second-leg match. Of course, he is available for selection in the Champions League. Valdes is the clear choice at the back for Barcelona.
Dani Alves, at right back, is another pretty clear choice. The veteran Brazilian has been a mainstay on this side since his arrival from Sevilla, and will be heavily relied on here. His pace down the flank must be utilized to its fullest to attack Milan's back line.
The central defense pairing starts with an easy choice in Gerard Pique. The undisputed rock at the back for this side, Pique has been the pick of the lot amongst Barca defenders this season. His size in particular will be a key aspect in controlling play. Plus, he's rested having not featured against Deportivo.
Who should partner Pique is a tough choice. Carles Puyol has been beaten quite a bit lately, but was solid on Saturday and could see a second straight start. Javier Mascherano would be the second option, though he is similar to Puyol in lacking the pace to counter Stephan El Shaarawy.
I've chosen Adriano over Jordi Alba at left-back because of the former's better defensive abilities, as well as his overall level of play this season. Maintaining some sort of balance is important as Dani Alves bombs up the right, so you'll want a slightly more defensive option on the other side.