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Having somewhat controversially been left out of the starting XI to take on Real midweek, Wayne Rooney is expected to make a return to the Red Devils' lineup against Chelsea.
Last weekend's hat-trick hero Shinji Kagawa is also likely to feature, as is Antonio Valencia following his impressive display vs. Norwich City.
In defence, Jonny Evans is almost certain to start, though who his partner will be is another question altogether.
Chelsea's interim boss Rafa Benitez is likely to keep faith in the team that defeated West Bromwich Albion last weekend, with Demba Ba starting in attack over the misfiring Fernando Torres.
The one exception may be club captain John Terry, who has spent a good deal of time sitting on the bench in past few weeks for the Blues.
Manchester United: David de Gea, Rafael, Jonny Evans, Nemanja Vidic, Patrice Evra, Michael Carrick, Anderson, Antonio Valencia, Wayne Rooney, Shinji Kagawa, Javier Hernandez.
Chelsea: Petr Cech, Cesar Azpilicueta, John Terry, David Luiz, Ashley Cole, Ramires, Frank Lampard, Eden Hazard, Oscar, Juan Mata, Demba Ba.