Midwest No. 2: Georgetown
The Hoyas lose the argument to Indiana, thanks to the aforementioned loss to the Hoosiers.
They have a bad loss to South Florida. They only have four wins in the RPI Top 25 through March 6.
The No. 1 seed in the Big East Tournament has only won the event twice in the last 10 years.
If Georgetown closes the regular season on a 13-game winning streak and wins the Big East Tournament, the Hoyas are clearly a No. 1 seed. But with games at Villanova and at home against Syracuse before the journey to Madison Square Garden, that's too much to ask.
Georgetown will lose one of its final two regular-season games and come up short in the Big East Tournament.
The Hoyas could get the opportunity to meet the Hoosiers again in the Elite Eight, in Indianapolis.
South No. 2: Michigan
Trey Burke has won some big games for the Wolverines at home in crunch time. However, Michigan has struggled against some of the bigger teams away from home.
The Wolverines haven't won outside of Ann Arbor since January 27, with one of their losses coming against Penn State—their only conference win.
Even if Michigan wins at Purdue and defeats Indiana at home to close the regular season, the Wolverines will exit early in the Big Ten Tournament.
The lack of size will cost them on Friday or Saturday, and the Wolverines need to win the tournament if they want a No. 1 seed.
East No. 2: Michigan State
Michigan State is one of the four best teams in college basketball, but the Spartans don't deserve a No. 1 seed.
Seven losses is just too many, even if the Big Ten is the best conference in the nation.
If Michigan State wins out and takes home the Big Ten Tournament trophy, the Spartans will at least have a case for a No. 1 seed. Although, Indiana has beaten them twice this season and will make it a third time in the Big Ten Tournament finals.
West No. 2: New Mexico
Florida, Louisville and Miami fans won't like this, but they should want to be closer to home anyways.
New Mexico has arguably the most impressive resume in college basketball when it comes to consistency. The Lobos have knocked off 17 teams in the RPI Top 100 and will have a chance at an 18th when it travels to Air Force this weekend.
New Mexico will win the Mountain West Tournament, finish on a 10-game win streak and have 20 total wins against the RPI Top 100.
The selection committee will move the Lobos up to a No. 2 seed.