Manchester United: David de Gea, Rafael, Rio Ferdinand, Nemanja Vidic, Patrice Evra, Michael Carrick, Ryan Giggs, Nani, Wayne Rooney, Shinji Kagawa, Robin van Persie.
Real Madrid: Diego Lopez, Alvaro Arbeloa, Raphael Varane, Sergio Ramos, Fabio Coentrao, Xabi Alonso, Sami Khedira, Angel Di Maria, Mesut Ozil, Cristiano Ronaldo, Gonzalo Higuain.
Predicting the starting lineups that will take the field for the game has been one of the most fiercely debated topics for fans of both sides.
From a Manchester United perspective, the defence virtually picks itself with the exception of who will partner club captain Nemanja Vidic in central defence.
With Rio Ferdinand rested for the weekend's clash with Norwich, he appears the most likely candidate, though if Jonny Evans is given the responsibility, he should prove no less an alternative.
Sir Alex has already intimated that Welsh veteran Ryan Giggs will play some part in the action, most likely in holding midfield alongside Michael Carrick (via Sports Mole).
In attacking midfield, Nani and Antonio Valencia will battle for a place on the right wing, while Shinji Kagawa would be far more likely to start on the left flank in place of Ashley Young.
Jose Mourinho should name an almost identical team to the one which started at the Bernabeu three weeks ago, though Gonzalo Higuain could possibly replace Karim Benzema in attack.
Though Angel Di Maria has had his disagreements with Mourinho this season, he will play on the right side of attacking midfield, with German playmaker Mesut Ozil through the middle.
Pepe is a likely exclusion in central defence, with the young Raphael Varane his deserving replacement.