As the football season heads toward its final furlong, squads are rotating in a bid to offset the injuries that can build up at this point in a campaign.
Here we take a look at the latest casualties of the season from this weekend's action.
Phil Jagielka is facing surgery after leaving the field early on in the win over Reading.
Everton defender Phil Jagielka is rated doubtful for the FA Cup quarterfinal against Wigan Athletic next weekend after suffering a badly gashed ankle in the win over Reading at Goodison Park.
The England international left the field after just four minutes following a challenge by Royals striker Adam Le Fondre, which angered Everton manager David Moyes (via evertonfc.com).
Everton and United States goalkeeper Tim Howard missed out on breaking Neville Southall's club record of 212 consecutive league matches by just two games, following a back injury suffered in the midweek FA Cup win over Oldham Athletic.
But Howard is expected to be fit for the game against Wigan next weekend.
Abou Diaby missed the north London derby at Tottenham.
Arsenal manager Arsene Wenger will have to play a waiting game over Abou Diaby.
The midfielder was ruled out of the North London derby at Tottenham with a calf injury he picked up in the win over Aston Villa last weekend.
Wenger will monitor Diaby during the week, but the Gunners do not play until Mar. 13 when they face Bayern Munich in the Champions League last-16 second leg in Germany.
Braga and Portugal striker Eder has been ruled out for the rest of the season.
Braga striker Eder has been ruled out for the remainder of the season after tearing his cruciate knee ligament.
The Portugal international was carried off the field during Braga's cup win over Benfica on Wednesday night.
The 25-year-old underwent surgery on Friday and will miss his team's quest for Champions League qualification this season.
QPR goalkeeper Julio Cesar was forced out of the game at Southampton with a back injury.
The Brazil international suffered a leg injury during the 2-1 win at the St Mary's Stadium and was replaced by England international Rob Green.
Cesar picked up a dead leg in a challenge with Southampton's Jay Rodriguez and will now be assessed by the Loftus Road medical staff.
Zenit St Petersburg defender Domenico Criscito has been ruled out for the season.
The Italy international suffered the injury in a friendly match against AC Siena on Thursday and left the field on a stretcher.
Criscito, 26, who joined Zenit from Genoa in 2011, will now miss the rest of the Europa League campaign and the Russian league season.