Sergio Ramos's late header added more misery to Barcelona, as Real Madrid won another installment of El Clasico 2-1 at the Bernabeu.
Both managers made changes from the midweek Copa clash, but it was Mourinho's much changed side that took an early lead.
Youngster Alvaro Morato produced a fantastic cross which Karim Benzema took no exception to prodding home.
Barca were soon level though, Lionel Messi scoring for in his 15th consecutive La Liga match and equalling the 18 Clasico goals scored by Alfredo Di Stefano.
The match went up a few gears around the hour mark though, following the introduction of Cristiano Ronaldo.
Despite coming close, it wasn't the Portuguese forward that stole the headlines but Sergio Ramos.
The defender thundering home a header as the match ended amid controversy as Barcelona were denied what they felt was a clear cut penalty.
More reaction to follow on Bleacher Report...
La Liga: Satiago Bernabeu, Madrid (10 a.m ET)
Real Madrid 2-1 (Benzema, Ramos - Messi) Barcelona (Full time)
Real Madrid: Lopez; Varane, Ramos, Pepe, Coentrao (Arbeloa); Essien, Modric; Kaka (Khedira), Callejon, Benzema (Ronaldo); Morata
Barcelona: Valdes; Alves, Pique, Mascherano, Alba; Busquets, Thiago (Tello), Iniesta; Villa (Alexis Sanchez), Messi, Pedro (Adriano)