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Tim Howard; Seamus Coleman, Phil Jagielka, Sylvain Distin, Leighton Baines; Kevin Mirallas, Leon Osman, Darron Gibson, Steven Pienaar; Marouane Fellaini; Nikica Jelavic.
This is a probable lineup for the Toffees, although there's a number of ways David Moyes could go.
Phil Neville and Mirallas sat on the bench against Norwich and will both be close to selection here. The Belgian could well slot in for the disappointing Steven Naismith, but finding a place for Neville isn't so easy.
If Coleman's capable of another game so soon after his return from injury then he will stay at right-back, leaving Neville needing to elbow his way into midfield.
Osman, Gibson and Pienaar are three players all in need of a rest, and while Moyes could fit his captain in here, it's unlikely he would drop such key performers in such a critical match for his side.
Therefore, it seems Neville may miss out.
Elswhere, Moyes initially opted to use Fellaini in a deeper role during the first tie to combat Oldham's physicality; however, Anichebe's likely absence will limit his attacking options meaning Fellaini will be needed further forward.
Jelavic will again lead the line and will be desperate to find the back of the net and rejuvenate his flagging season.
Dean Bouzanis; Connor Brown, Jean-Yves M’Voto, James Tarkowski, Jonathan Grounds; Lee Croft, James Wesolowski, Jose Baxter, Jordan Obita; Matt Smith, Lee Barnard.
As far as Oldham are concerned, Smith's success in the previous round, and again against Everton, should see him slot in, possibly for Chris Iwelumo.
Elsewhere, as long as Wesolowski recovers, it should be same again for the Latics as they bid to reach the final eight.