After a first half that was packed with missed opportunities, Chelsea came out on fire in the second half.
Juan Mata opened the scoring in the 54th minute before Frank Lampard, Oscar and John Terry contributed to the winning effort with a goal each.
The Blues will now visit the Riverside Stadium to play Middlesbrough in the fifth round on February 27.
Here are five things we learned from Chelsea's fourth round triumph.
From the opening kick of Sunday's match, Juan Mata was running up and down the pitch providing scoring opportunities for his teammates.
Since none of the chances in the first half went into the back of the net, Mata took matters into his own hands as he sent a shot past Brentford keeper Simon Moore in the 54th minute.
Mata also sent in a cross in the 71st minute that found the foot of Frank Lampard, who then casually struck home the third Chelsea goal.
Going into the match, Mata had a club-high 12 assists and as his play continues to impress, the Chelsea attack continues to score on passes provided by the Spaniard.
Chelsea legend Frank Lampard continued his impressive form with a goal in the 71st minute that was a trademark strike from the midfielder.
Lampard was left wide open in the penalty area and he gracefully struck home the pass he received from Mata.
The goal was Lampard's 199th goal for Chelsea, which puts him just three behind Bobby Tambling for the all-time club lead.
Lampard could have reached the 200-goal mark on Sunday but he missed two chances in front of the goal in the first half.
Victor Moses was handed the start on the right wing against Brentford and he did quite well for the Blues before he was taken off in the 65th minute.
Moses showed off plenty of ball control skills and although he did not provide any shots on goal like Mata and Oscar, he was held his own in the Chelsea starting 11.
While he is currently behind Eden Hazard on the depth chart, Moses could be shifted to the forward position due to his versatility.
With the Blues progressing further into the FA Cup, Moses may be one player who will get playing time in the competition especially if Chelsea are still involved in the Europa League.
As he showed on Sunday, when he is put in the starting 11 he is capable of putting in a solid work rate for the Blues.
No club has been more dominant in the FA Cup in recent years than Chelsea.
The Blues have won four of the last six FA Cups and they are on track to go far once again in the tournament.
With the EPL title out of reach and the Europa League still at the round of 32 stage, the best opportunity for Chelsea to win a trophy this season is in the FA Cup which has plenty of lower tier clubs left.
In the 39th minute, Brentford believed that they had gone ahead through a goal by Marcello Trotta.
However, that was not the case as referee Neil Swarbrick blew the play dead after Adam Forshaw went down following a challenge by David Luiz.
The resulting free kick would eventually turn into nothing and the two clubs went into halftime tied at 0-0.
If Swarbrick had allowed the advantage to be played, Brentford would have gone into the half up by a goal and would have come out in the second half with plenty of confidence.
Instead, the match was tied at halftime and Chelsea opened the scoring nine minutes into the second half and Brentford's FA Cup run was ended.
What did you learn from Chelsea's victory over Brentford?
Comment below or leave me a comment on Twitter, @JTansey90.