The injuries came in the Red Devils' 2-0 win over Everton in the English Premier League on the weekend, with both players forced to leave the field during the second half.
Manchester United's preparations for their Champions League showdown with Real Madrid have been hit by two fresh injury blows.
United face Jose Mourinho's side at the Bernabeu on Wednesday but could be without Phil Jones and Jonny Evans who were forced off with injury in United's 2-0 win over Everton at Old Trafford this afternoon.
Ferguson could now be left with a defensive headache for his side's trip to Spain.
Evans in particular has been superb for United so far this year—filling in brilliantly whilst captain Nemanja Vidic was sidelined with injury earlier in the year.
United have not confirmed the information on either player, with both likely to be assessed sometime on Monday as to their likelihood of participating in the Champions League squad.
Should both players be ruled out, the Red Devils do have a number of other defensive options, starting with Vidic and Rio Ferdinand, but there is little doubting that their defense will be impacted by the absence of both Jones and Evans.
Coming up against one of the most potent attacks in world football, Sir Alex Ferguson would have loved for his side to be completely healthy, but in particular his defenders, who have struggled with injuries throughout the season as a whole.
They would be down to just Chris Smalling as a potential replacement for either Vidic or Ferdinand, should they need replacing at some point, and may have to drag midfielder Michael Carrick back into central defense if need be.
Which, when you're playing one of the greatest attacks in the world featuring the likes of Karim Benzema, Mesut Ozil and Cristiano Ronaldo, is not the best position to be in.
United haven't won when playing away to Madrid and have arguably their strongest squad on hand to try to progress through their Round of 16 encounter this year.
However, with their latest injury news, that quest just got a whole lot harder.
Will Manchester United beat Real Madrid in the Round of 16?
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