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Andrea Pirlo will look to run the show for Juventus.
First Leg: 12 February; Celtic Park (Glasgow)
Second Leg: 6 March; Juventus Stadium (Turin)
On paper, many people would consider this a relatively one-sided matchup. After all, we are talking about Juventus, the current Scudetto holders, a club which boasts a midfield rivaled only by that of Barcelona.
But as Celtic showed in the group stage, even Barcelona are not invincible. The Bhoys shocked almost everyone when they defeated the Catalan giants 2-1 at home, with that positive momentum guiding them to a place in the last 16.
And they've been justly rewarded with a duel against Juventus, who continue to coast at the top of the Serie A pyramid. With a squad like theirs, who would bet against them going through at this point?
This is not a team without problems, though. Their strike force is not the most prolific in the world, and the Bianconeri have relied a lot on midfield lynchpins Arturo Vidal and Andrea Pirlo to fill the void when needed. Additionally, they will be without defensive stalwart Giorgio Chiellini due to injury.
Considering Celtic's strong attacking force, featuring the likes of prolific scorer Gary Hooper and versatile attacker Georgios Samaras, this could be a big problem for Juve in the first leg. Their 3-5-2 leaves no room for error at the back, and this is something Neil Lennon's men will look to exploit.
Granted, it may be tough for them to get on the ball. Juventus, like Barcelona, will dominate possession, with every move in the match going through Andrea Pirlo in the middle of the park. But if his teammates fail to capitalize, Celtic could do what they did to Barcelona and hit out on the counter.
So despite the mismatch in pure talent, this matchup is sure to be a thriller over the two legs. I expect Juventus to do just enough in the first leg so that, with a healthy Chiellini likely back come March, they can be a bit more comfortable at home and move on.