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GK: David de Gea
In the midst of all the criticism aimed at David de Gea for the late goal United conceded against Tottenham Hotspur, Sir Alex emphasized his faith in his young goalkeeper by starting him in the FA Cup tie against Fulham. The Spanish shot-stopper repaid the manager's faith as United ran out 4-1 winners.
LB: Patrice Evra
United's No. 1 left-back Patrice Evra was not rested for the FA Cup against Fulham, but instead played the full 90 minutes. It's highly likely that he'll be dropped for this important league game unless he is injured.
Despite all the headlines that Robin van Persie has made since his arrival at Old Trafford, there is a strong case for inserting Rafael as United player of the season so far. The Brazilian full-back has matured into his role in the team, and United have been better for it.
CB: Nemanja Vidic
Clearly still one of the best defenders in world football, the Serbian defender was rested for the FA Cup, but should regain his place in the starting lineup against Southampton.
CB: Rio Ferdinand
The England international was also rested against Fulham, with Sir Alex opting to give a run out to Phil Jones and Chris Smalling. It is clear to see that Sir Alex is desperate to get a bit of continuity and solidity in defense going, so Ferdinand is the perfect choice for this moment.