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The Ducks have a bit of experience with this issue after all-conference safety John Boyett went down for the season in the second week of the 2012 season.
Inexperienced studs like Ifo Ekpre-Olomu and Avery Patterson revived the secondary with outstanding play, addressing the problem almost immediately.
However, heading into the 2013 season, the Ducks are hurting at linebacker after losing Michael Clay, a true leader on the team, and Kiko Alonso, not to mention Dion Jordan, a likely future first-round pick.
The news of Anthony Wallace's transfer from Oregon certainly doesn't help the team's already thin corps of linebackers, but they do have the talent to get the job done.
Boseko Lokombo has been an underrated gem for the Ducks over the last three seasons, and will head into 2013 as one of the most experienced veterans on the squad. The athletic senior has a knack for making big plays when his team needs him, accumulating four interceptions and four defensive touchdowns in his career.
On the outside, Oregon also has some intriguing young players such as Derrick Malone and Tyson Coleman, who both showcased their talent in limited playing time in 2012.
The real challenge here will be finding a solid centerpiece to play in the middle. Most Duck fans assumed Wallace would be next in line for that spot in the wake of Alonso's departure, but with him transferring, Oregon doesn't have too many big, full linebackers capable of playing in the middle.
Replacing studs like Clay, Alonso and Jordan won't be easy. Oregon's surprising, and often unsung, defensive accomplishments played a big part in the team's success in 2012, and the Ducks will need to find new leaders at some key defensive positions in 2013.