Tim Howard; Phil Neville, Phil Jagielka, John Heitinga, Bryan Oviedo; Steven Naismith, Marouane Fellaini, Leon Osman, Steven Pienaar; Kevin Mirallas; Victor Anichebe.
Judging by his lineup in the previous round at Cheltenham, it seems David Moyes is intent on playing his strongest side throughout the FA Cup. Therefore, expect Tim Howard to start in goal.
In front of him, Leighton Baines has been playing with an ankle injury and may get a rest, allowing Oviedo to come in. The Costa Rican has recently impressed in Everton's second-string and is due a run-out.
Elsewhere, in defence, Heitinga may be given a game to allow Sylvain Distin an afternoon off, but otherwise Moyes is likely to go for his strongest selection.
Further up the pitch, Moyes could well deploy his midfield as they finished on Monday. That would mean Fellaini dropping deeper with Osman in the middle, flanked by Pienaar and Naismith.
In attack, Anichebe was one of the few to impress against Southampton. The Nigerian should start, and it would make sense to bring in Mirallas just off him, to step up his return to fitness.
After a patchy few months, Nikica Jelavic may be used from the bench in this one.
Alternatively, Moyes could opt for Mirallas as a substitute, or in place of Naismith, and keep Jelavic in attack, supported by Anichebe.