The fights start at 4:30 p.m. ET on Facebook, but the main card will air on Fox at 8 p.m. ET.
Flyweight champion Demetrious "Mighty Mouse" Johnson (16-2-1) defends against the explosive John "The Magician" Dodson (15-5) live at the United Center in Chicago on Saturday night.
Though many fans favor watching the bigger guys bang, the little guys shouldn't be slept on. Johnson is one of the UFC's most respected and well-rounded champions.
He's shown the ability to strike effectively, and his grappling is elite.
Dodson has tremendous power in his hands, and that is evidenced by his KO's of T.J. Dillashaw and Jussier "Formiga" Da Silva since joining the UFC.
This is clearly designed to be the highlight of the Fox presentation, but as we all know, major UFC events are generally cut into three parts.
The blessed Facebook live streamed preliminary fight, the FX or Fuel TV preliminaries, and then the main card on pay-per-view—or in this case on Fox.
Here's a look at the confirmed bouts and the matchups from each segment that figure to highlight each broadcast.
Facebook Preliminary - 4:30 pm ET Live on Facebook
Simeon Thoresen (17-3-1) vs. David Mitchell (11-2)
The last time we saw Thoresen, he was being separated from consciousness by a left hook from Seth Baczynski in the first round of their fight at UFC 152.
Despite the fact that he seemed to be in control of the bout up to that point, the crushing blow is the indelible image we have of the Norwegian welterweight.
He will be working to change that image in this bout with Mitchell.
Even though Mitchell has compiled an impressive overall record, he's 0-2 in the UFC. This could be a make-or-break performance for his future with the promotion.
FX Preliminaries - 5 pm ET
Lightweights - T.J. Grant (19-5) vs. Matt Wiman (15-6)
Lightweights - Clay Guida (29-13) vs. Hatsu Hioki (26-5-2)
Welterweights - Mike Stumpf (11-3) vs. Pascal Krauss (10-1)
Heavyweights - Mike Russow (15-2) vs. Shawn Jordan (13-4)
Middleweight - Rafael Natal (14-4-1) vs. Sean Spencer (9-1)
Light Heavyweights - Ryan Bader (14-3) vs. Vladimir Matyushenko (26-6)
Explosive KO Possibilities
Bader is coming off a devastating defeat at the hands of Lyoto Machida at UFC on Fox 4. He was completely outclassed and stopped in the second round of that bout.
He's looking to collect himself for another run at the light heavyweight title, though I strongly doubt he'll fare any better against Jon Jones in a rematch.
Bones also humbled Bader with a guillotine at UFC 126.
Matyushenko is a 42-year-old, 32-fight MMA veteran. His best days are behind him, but he still packs a huge punch. He isn't likely to outwork a man 13 years his junior, but he still brings some power.
This fight could very well be the source for KO of the night.
Main Card on Fox - 8 pm ET
UFC Flyweight Championship - Champion - Demetrious Johnson (16-2-1) vs. John Dodson (14-5)
Featherweights - Erik Koch (13-1) vs. Ricardo Lamas (12-2)
Light Heavyweights - Quinton “Rampage” Jackson (32-10) vs. Glover Teixeira (19-2)
Rampage's Swan Song
This is another opportunity to see an explosive ending. Both of these men like to trade in the stand-up, and both pack a huge punch.
In what figures to be Rampage's last fight in the UFC (Yahoo! Sports), he'll be looking to go out with a bang.
Teixeira is a skilled and experienced fighter that appears to be on his way to a title shot in the next year or so. But first, he has to get by Rampage.
Even at 34 years old, the UFC's most polarizing star isn't an easy win.
Lightweights - Anthony Pettis (15-2) vs. Donald Cerrone (19-4)
Showtime and the Cowboy
I'm just as excited about this fight as I am about the main event. Pettis is one of the most exciting and dynamic fighters in MMA today.
Remember this move off the cage against Benson Henderson while both were in WEC?
He's still the last man to defeat Henderson, and this bout is clearly very important for determining which of these contenders gets a title shot first.
Cerrone survived a scary encounter with Melvin Guillard in his last bout. He was rocked early by the hard-punching, but inconsistent Guillard, but came back to stop him later in the first round at UFC 150.
This could be an amazing battle.