Atletico Madrid striker Radamel Falcao will be out for three weeks.
The Colombia international is one of the most sought after names in world football at the moment, but the forward will now be absent for up to three weeks, according to a report on Fox Sports.
Falcao was withdrawn from the game in the second half after pulling up after stretching for the ball. He is now expected to miss the club's next three matches, including the Copa del Rey quarterfinal against Real Betis on Thursday.
The 26-year-old has scored 18 goals in 17 La Liga appearances for Atletico, helping them into second place behind Barcelona in the table.
Here we look at the progress of other injured players across world football.
Manchester City captain Vincent Kompany could be out for several weeks.
The Belgium international limped out of the FA Cup fourth-round win at Stoke City on Saturday with a calf injury and will discover the full extent of the problem this week.
The 26-year-old is likely to miss the Premier League matches against QPR, Liverpool and Southampton but should be fit to face Chelsea at the Etihad Stadium on Feb. 24.
Tottenham striker Jermain Defoe has been playing despite a pelvic problem.
The England international has been playing through the pain barrier in recent weeks, but has scored just once in his last eight appearances for Spurs.
Cristian Chivu celebrates his goal for Inter Milan during the 2-2 draw with Torino.
The Romania international withdrew from the game on the half-hour mark after giving Inter the lead.
However, Chivu told Inter Channel (as reported by football-italia.net) that he only expects to be missing for a short period.
Arsenal midfielder Mikel Arteta remains sidelined.
The Spaniard picked up the injury in training ahead of the 2-0 defeat at Manchester City on Jan. 13.
Gunners midfielder Tomas Rosicky is also recovering from a calf injury but should also return to action soon.
Yohan Cabaye has been badly missed by Newcastle in recent weeks.
The France international has recovered from a groin injury, but manager Alan Pardew said that the club—who are facing a potential relegation battle this season—must not rush the 27-year-old in an interview with the Newcastle Evening Chronicle.
Cabaye is viewed as a leading candidate to succeed defender Fabricio Coloccini as captain if the Argentina international leaves the club this month.
Tottenham midfielder Sandro is out for the rest of the season.
Tottenham midfielder Sandro is out for the rest of the Premier League season after undergoing knee surgery.
The Brazil international picked up the injury during his team's goalless draw at Queens Park Rangers on Jan. 12. BBC Sport reported his season-long absence.
Scott Parker, however, is back to full fitness after Achilles surgery in the summer and made his first start since April when he replaced Sandro in the team for Sunday's 1-1 draw with Manchester United.
Sergio Aguero returned for Manchester City at the weekend.
The Argentina international has not played since New Year's Day, when he limped out of the win over Stoke City with a hamstring injury.
Meanwhile, City coach David Platt played down fears over defender Pablo Zabaleta, who was forced off the field against Fulham on Saturday. Zabaleta was suffering from an ankle problem, as reported by the Press Association (via Eurosport/Yahoo).
Liverpool goalkeeper Pepe Reina suffered a broken nose at Manchester United over a week ago.
The 30-year-old was injured in a collision with Shinji Kagawa during the defeat at Manchester United on Jan. 13 and missed Saturday's win over Norwich City at Anfield.
Australian goalkeeper Brad Jones deputised for Reina, who has been linked with a move to Barcelona in a Daily Mail report.
Reina, who has also been nursing a thigh injury, is expected to return for the Premier League game against Arsenal on Jan. 30.
PSV defender Erik Pieters is nursing a cut arm and his pride after this weekend.
The Holland international has only recently returned from a long-term foot injury, but was sent off during the surprise defeat to PEC Zwolle on Friday.
The 24-year-old kicked a door and smashed a glass window on his way back to the dressing room, leading to a major cut to his arm, according to another report in the Daily Mail.