The Colombia international is one of the most sought after names in world football at the moment, but the forward will now be absent for up to three weeks, according to a report on Fox Sports.
Falcao was withdrawn from the game in the second half after pulling up after stretching for the ball. He is now expected to miss the club's next three matches, including the Copa del Rey quarterfinal against Real Betis on Thursday.
The 26-year-old has scored 18 goals in 17 La Liga appearances for Atletico, helping them into second place behind Barcelona in the table.
Here we look at the progress of other injured players across world football.