FA Cup holders Chelsea will travel to Brentford in the fourth round.
The Griffin Park side defeated Southend United of League Two 2-1 to set up a lucrative home clash with holders Chelsea in the fourth round.
Bolton Wanderers of the Championship claimed the biggest scalp in Tuesday night's replays when two goals from Marvin Sordell knocked top-flight Sunderland out of the competition at the Stadium of Light.
Wigan Athletic needed a defensive lapse to claim victory at League One Bournemouth.
Mauro Boselli, left, scored the only goal of the game for Wigan at Bournemouth.
An unfortunate error by Bournemouth midfielder Harry Arter gave Wigan Athletic victory at Dean Court.
The Premier League side opened the scoring in the 18th minute when Arter's poor pass gifted the ball to Mauro Boselli, who struck it beautifully into the top corner of the net from 25 yards.
However, the Cherries worked hard for an equaliser for the rest of the game with Marc Pugh forcing Wigan goalkeeper Ali Al-Habsi into a brilliant save on to his crossbar.
But Roberto Martinez's side held on to claim a fourth-round trip to non-league Macclesfield Town.
Jon Walters scored twice as Stoke City defeated Crystal Palace 4-1.
A shock result had looked on the cards when Palace substitute Glenn Murray cancelled out Kenwyne Jones' 69th-minute opener with his penalty three minutes from the end of normal time.
In the fifth minute of extra-time, Walters, who scored two own goals and missed a penalty against Chelsea on Saturday, put Stoke ahead with a header before making it 3-1 15 minutes later when he connected with a Jones cross.
Cameron Jerome added the fourth for Stoke in the 120th minute when he rounded Palace goalkeeper Lewis Price before hitting home.
Palace had missed a great opportunity to take the lead in the 30th minute when Wilfried Zaha was brought down by Ryan Shawcross inside the area. Jermaine Easter stepped up for the penalty but Stoke goalkeeper Thomas Sorensen got a touch to the ball to turn it around for a corner.
Stoke will now play host to Manchester City in the fourth round in a repeat of the 2011 FA Cup final.
Marvin Sordell celebrates his opener for Bolton at Sunderland.
Despite dominating the game for long periods, the Black Cats could not find a way past Bolton goalkeeper Andy Lonergan and paid a heavy price.
Against the run of play, Bolton took the lead on the hour mark when Jack Colback brought down Darren Pratley inside the area. Sordell stepped up for the penalty and blasted it past Sunderland goalkeeper Simon Mignolet.
In the 73rd minute, Bolton doubled their lead with Sordell adding to his tally for the evening. Tyrone Mears was the architect, pulling the ball back for Sordell to fire home.
Nathan Delfouneso celebrates his opener for Blackpool but Fulham hit back to win the tie at Bloomfield Road.
Ten minutes from the end of the game, the impressive hosts took the lead. A poor clearance from Fulham goalkeeper Mark Schwarzer fell to Nathan Delfouneso, who struck home to give Blackpool the lead.
But, in the 90th minute, Kieran Richardson forced the tie into an additional 30 minutes when he fired home the equalizer.
QPR striker Jay Bothroyd heads home the winner at West Brom.
QPR stunned their hosts when they opened the scoring with 15 minutes left in the tie. Alejandro Faurlin swung over a corner and striker Jay Bothroyd rose highest to head home for Harry Redknapp's side.
QPR will now welcome MK Dons to West London in the fourth round.
Former Brentford goalkeeper Paul Smith could not prevent his old club progressing to an FA Cup date with Chelsea despite saving a penalty for Southend.
Brentford 2 Southend United 1
Paul Hayes had opened the scoring for Brentford but League Two Southend rallied and claimed an equalizer through Barry Corr.
Former Brentford goalkeeper Paul Smith was inspired form against his old club and saved a penalty from Harry Forrester among a series of great saves.
But former Hibernian and York striker Donaldson needed a deflection to beat Smith for the 76th-minute winner.
Birmingham City 1 Leeds United 2
Wade Elliott had given Birmingham City a first-half lead when he connected with Nathan Redmond's cross.
But Diouf then set up Ross McCormack to equalize in the 70th minute before hitting the winner himself from the penalty spot six minutes later after Paul Robinson handled inside the area.
Leyton Orient 1 Hull City 2 (after extra-time)
Hull had taken the lead in the 41st minute when Nick Proschwitz headed home Liam Rosenior's cross from the right.
The visitors hung on until three minutes from the end of normal time when Dean Cox found the net from Moses Odubajo's flighted ball.
However, with five minutes left in extra-time, Tom Cairney hit the winner for Steve Bruce's side, who will now play host to fellow Championship side Barnsley in the fourth round.
MK Dons 2 Sheffield Wednesday 0
Shaun Williams opened the scoring for the Dons from the penalty spot in the 28th minute after Lewis Buxton pulled back Dean Bowditch in the area.
Bowditch sealed a fourth-round tie at Queens Park Rangers when his 75th-minute free-kick somehow bounced past Wednesday goalkeeper Stephen Bywater.