Yep, it's the Patriots...again.
The 49ers traveled to Foxborough back in Week 15, a game in which Kaepernick threw four touchdown passes and San Francisco survived a furious second-half comeback to emerge with a 41-34 victory.
The same things that propelled the 49ers to a win in that game are the ones that could land the team the Lombardi Trophy.
The 49ers enjoy a significant edge on defense. While the Patriots have improved somewhat in that regard, they remain susceptible to the pass, ranking 29th in the NFL in that regard.
However, the Patriots were a top-10 run defense in 2012, and a key to the game would be for the 49ers to contain defensive tackle Vince Wilfork and keep him from disrupting the power run game and option attack.
It's something of a different story on offense, and the issues that nearly allowed the Patriots to come back in December are still there.
The Patriots are as dynamic offensively as any team in the NFL, especially when they employ their no-huddle offense, and tight ends Rob Gronkowski and Aaron Hernandez present matchup nightmares for opposing defenses.
The key to slowing New England down is to do just that. Disrupt quarterback Tom Brady's rhythm with pressure and stop the team from getting into an offensive groove that allows them to run the hurry-up and wear down the defense.
There's also the experience factor.
Granted, Colin Kaepernick was outstanding in his first career playoff start, but the Super Bowl is a different animal. The pressure and distractions that go with playing in the game have rattled many players, including some of the best to ever play in the NFL.
Should Brady make it to the Superdome, it would be his record sixth Super Bowl, although he would face a different sort of pressure all his own after coming up short his last two tries.
As things stand today, given how the 49ers looked in dismantling Green Bay, a San Francisco-New England Super Bowl appears the most likely potential matchup.
At least I hope so, because that, much like their first meeting, would be one lulu of a football game.