The Packers lead the series 4-1.
Candlestick Park has been the locale for three of the postseason games between the two squads, although the stadium was called 3Com Park in those days.
The Packers won two of those three games (including the 1997 NFC Championship Game), with the only loss coming on a 25-yard touchdown pass from Steve Young to Terrell Owens with just three seconds remaining in the game, as the Niners won 30-27 in the 1998 NFC Wild Card Playoff game.
In an ironic twist, in those previous three contests, the Packers had a head coach (Mike Holmgren) who was born and raised in San Francisco and had been on Bill Walsh's staff before he was hired by the Packers.
There will be more irony on Saturday night as quarterback Aaron Rodgers of the Packers plays against a team that he always wanted to play for, growing up just three hours to the north of San Francisco, in Chico.
The game will most likely be a tight contest, so the Packers need to play to their strengths, but also cover up their weaknesses with various formations and schemes.
There are a number of keys to victory for the Packers, and I've listed five of them.