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Cagliari are in a spot of bother, and the Isolani are desperate for three points to haul themselves out of the relegation zone.
Genoa are currently hovering one place above the relegation zone and have gone three games unbeaten under Luigi Delneri.
Only a point separates these two teams, who will both feel that they should not be anywhere near the drop.
Players to watch
Marco Sau (Cagliari): With the absence of Mauricio Pinilla through injury, Cagliari have been dependent on Sau to deliver the goals to win them games.
The 25-year-old was playing in Serie B last season for Juve Stabia but has adapted magnificently to life in Serie A, ousting the likes of Victor Ibarbo, Nene, and Thiago Ribeiro to become the first choice striker.
A clinical finisher, who is always lively in the area, Sau is proving to be a real match winner.
Francelino Matuzalem (Genoa): Recently acquired from Lazio—who froze the Brazilian out for non-footballing reasons—Genoa are offering the player a lifeline in his Serie A career.
Capable of dictating the flow of the game from deep, where Juraj Kucka will partner him and carry out the dirty work, Matuzalem is just the sort of player to bond this team of individuals together.
Key to the game
With Andrea Cossu suspended after his red card in the last game, Cagliari will need to reshuffle their midfield, possibly fielding Radja Nainggolan as an unorthodox attacking midfielder.
If the Isolani can devise a way to provide Sau and Pinilla with some good service, then Cagliari will have a chance of winning this game.