The rivalry between the two was always heated, but after Luis Suarez's racial abuse, the intensity went up a notch. Even a year after the controversy, the hot embers have yet to be extinguished.
United will be looking to extend its lead atop the Premier League table, while Liverpool wants to build on consecutive league wins.
Here's everything you need to know about the upcoming fixture.
Where: Old Trafford, Manchester, England
When: Sunday, Jan. 13, at 8:30 a.m. ET
Watch: Fox Soccer
Stream: FoxSoccer 2Go
What's at Stake?
It doesn't matter where either club sits in the table; the bragging rights involved in coming away with a victory are immense.
The Reds will want to get revenge for the 2-1 loss at Anfield back in September—Jonjo Shelvey was sent off in controversial fashion, as United defender Jonny Evans looked to go in with two feet.
Liverpool wants to try and build momentum toward a surge up the table in the second half.
United, on the other hand, are living quite comfortably at the top. The club sits seven points ahead of second-place Manchester City. It's not an unassailable lead, however, so dropping points could be critical, especially with the way last year ended.
What They're Saying
Paul Scholes still maintains Liverpool are the Red Devils' main rivals despite the club's fall from glory. According to The Guardian, he said:
Whether Manchester City have overtaken Liverpool now [as United's biggest rivals], I don't know; it'll probably take years for City to create what Liverpool have done.
Liverpool historically are our biggest rivals, they're always the biggest games and the best atmospheres. But I'm sure City will run them close.
Liverpool are looking to bring in reinforcements during the January transfer window. Manager Brendan Rodgers has a plan in mind for the kind of players he was to target. He said (via The Guardian):
My big thing is getting young players in here from the local area in Liverpool. Look at the history here – Carragher, Gerrard, McManaman, Fowler and Owen. Who have been the best two English players in the Premier League in the last six or seven years? Steven Gerrard and Wayne Rooney. Both scousers, not from a million miles apart, so you are not telling me there is not top young talent out there in Liverpool.
It is sexy to look at Spain and I am someone who loves working with European players. All my life I have worked with players from different parts of the world. But we mustn't forget what is on our doorstep and, for me, this is a hot-bed for footballers who have passion, hunger and incredible qualities. Bringing that through is a massive part of my job and is something we are trying to put in place.
Manchester United Player to Watch: Robin van Persie
This may be low-hanging fruit, but Robin van Persie is the most influential player at the club right now. Manchester United would not be first in the Premier League without him.
In less than six months, the Dutchman has already become the Red Devils' talisman. His 16 goals lead the Premier League.
Van Persie is showing the same kind of ability to single-handedly carry a club that he did at Arsenal.
Liverpool Player to Watch: Lucas
The more Lucas progresses back to full fitness, the better Liverpool will play. You can tell that he hasn't quite fully recovered from injury, as he just doesn't look to have the pace he had last season.
Quite a bit of the reason Liverpool has struggled so much for the last season-and-a-half is the fact that it didn't have a proper replacement for Lucas and the things he brought to the Reds' midfield.
The Reds really dominated the midfield in the first matchup, before Shelvey was sent off. A key to the game will be controlling the ball to keep it away from the deadly United attack.
Most of the time, the matches that receive the most hype are the ones that disappoint the most. With so much on the line, each team is afraid to expose itself too much, so both teams play defensive football and look to hit on the counter.
Form is generally thrown out the window when it comes to big derbies, and this one is no different.
Although United are 21 points ahead of Liverpool, the Reds have a very good chance to go into Old Trafford and pick up three points.
That won't be the case, however, as this one will finish in a draw.
Manchester United 1, Liverpool 1