Since then, the Reds have gone down 2-1 (Rafa Benitez), 3-2 (Roy Hodgson) and 2-1 (Kenny Dalglish).
In 2009, though, it was the stuff of dreams for the Reds as they ran out rampant and deserved 4-1 winners in United's own back garden, having initially gone a goal down in the first quarter of the game.
Liverpool needed the three points to keep the title race going and though they ended the match still in second place, they had closed the gap to United to just four points.
United's lead only lasted five minutes as Fernando Torres, in the prime of his career, out-paced Nemanja Vidic who had a five-yard head-start to the ball, controlled his way into the area and finished perfectly into the far corner past Edwin van der Sar.
Even going in at half time on level terms would have been good enough for the Reds haven fallen behind, but almost everything Liverpool did that day went according to plan. After Steven Gerrard was felled in the penalty area by Patrice Evra, the captain slotted the resulting spot kick away himself to hand the Reds a 2-1 lead.
Into the second half, Liverpool continued as the better side, and Alex Ferguson was so enraged he made a treble substitution after 74 minutes—but three minutes later it was game over, as Vidic was shown a straight red card for hauling Gerrard to the ground, who was through on goal.
Fabio Aurelio took the resulting free kick, curling deliciously over the wall and into the net. There was even time for Andrea Dossena to lob home a fourth, for the Reds' biggest win over Manchester United since 1990.
The gap between the two sides as they head into Sunday's game is somewhat more pronounced these days, but Liverpool, now under the guidance of Brendan Rodgers, should be in a confident mood after some good performances and results of late.
It might not end up 4-1 this time, but the Reds have every chance of getting a positive result and continuing their long climb back up the table.