On that September day, Alex Smith (remember him?) led the 49ers to a surprising 30-22 victory over the Packers at Lambeau Field.
Each of these teams has grown and evolved since then, with Green Bay discovering a new offensive star in Randall Cobb and San Francisco making a midseason QB switch in favor of Colin Kaepernick.
So, where do the advantages lie for both teams?
Let's break down some of the biggest matchups within this game and find out who has the edge. At the end we will award one team with the overall advantage and figure out how we got there.
Get it? Got it? Good.
Let's start with the quarterbacks.