It has been a disappointing season for both squads, as the Eagles were eliminated from playoff contention weeks ago and the G-Men need a wish from a genie's bottle, a rabbit's foot and a miracle to make the postseason.
Both teams are coming off Week 16 losses and are basically playing for bragging rights on Sunday afternoon, but the Eagles beat the Giants, 19-17, in Week 4.
Here's your complete guide for Sunday's action.
Where: MetLife Stadium, East Rutherford, N.J.
When: Sunday, Dec. 30 at 1 p.m. ET
Live Stream: NFL Game Rewind
Betting Line: Giants (-7) via Bet Online
Over/Under: 46.5 (Bet Online)
With both of these teams playing like complete garbage of late, it makes for a really tough game to pick.
Who ya got?
I'd like to think the Giants will stomp the Eagles, but being one of the most inconsistent teams in football, you never know what you're going to get with New York.
That being said, I'm rolling with Philly and the seven points.
As far as the over/under, I'm going with the under.
According to Bovada, the total has gone under in eight of the Eagles' last nine games and 12 of the Giants' last 16 games while hosting the Eagles.
What's At Stake?
There's nothing at stake for Philly, but New York needs a win to keep its ultra-thin playoff hopes alive.
Eagles Injury Report (via USA Today)
QB Michael Vick—Concussion—PRB
DT Fletcher Cox—Concussion—QST
Giants Injury Report (via USA Today)
DT Chris Canty—Knee—QST
DE Justin Tuck—Shoulder—QST
S Kenny Phillips–Knee—QST
Fantasy Start 'Em, Sit 'Em and Sleeper
Start 'Em: Victor Cruz
Victor Cruz is the Giants' best receiving option and thus becomes your best fantasy option this Sunday.
Cruz has a history of big games against the Eagles—think back to Week 3 of last season—including his nine receptions, 109 yards and a touchdown against Philly in Week 4 of this season.
The Eagles have surrendered 28 passing TDs in 2012, which ranks 28th in the NFL.
If Manning and Cruz are on the same page on Sunday, fantasy owners are in for a big day.
Sit 'Em: Brent Celek
Brent Celek is the third-leading receiver for the Eagles, but he's not your man in Week 17.
Celek had just four receptions for 57 yards against New York earlier this season and hasn't caught a TD pass since Week 5 against the Pittsburgh Steelers—his only touchdown this season.
Philly's TE has just one 100-yard day this season and just hasn't been effective this year; then again, neither has any member of the Eagles' offense.
If you're starting Celek in Week 17, you probably shouldn't expect him to help you win.
Sleeper: Martellus Bennett
Bennett has been a nice surprise for the G-Men this season, going for 54 catches, 611 yards and five touchdowns.
He didn't have a good day against Philly earlier this season, but he has been a favorite target of Manning in 2012.
Bennett has at least seven targets in three of his last four games and has an opportunity to make some noise against a poor pass defense on Sunday.
What They're Saying
Michael Vick is excited to be back under center for Philadelphia, according to ESPN, but says he's not auditioning for a job.
I'm not going out to audition for a job. I'm going out to try and win. My play and what I've done for this league and the accolades that I have speak for themselves. The thing I want to do is improve. Whatever happens next year happens.
ESPN New York's Ohm Youngmisuk reports that Eli Manning "misses his practice time with Hakeem Nicks," as the wideout has missed a lot of time this season with injuries.
"We're not making it easy on ourselves," Manning said. "It's just tough sometimes. Things aren't the same. Not quite as open, not quite as easy, everything is a little tougher. I don't think there is an exact reason."
Eagles Player to Watch: Michael Vick
If Vick does get the start for the injured Nick Foles, it'll be his first time playing since Nov. 11 against the Dallas Cowboys.
As cited earlier, Vick says he's not auditioning for a job next season, but we all know he is.
Where the 32-year-old QB plays next season could very well depend on his performance against Big Blue on Sunday.
I honestly believe he's still capable of a starting QB position in the NFL.
Giants Player to Watch: Corey Webster
Giants fans will have their eyes on Corey Webster on Sunday, as the 30-year-old corner will be a week removed from being dissected by Joe Flacco and the Baltimore Ravens' offense.
Webster was consistently picked on in Week 16 and you can bet Philadelphia took notice of his poor play against the Ravens.
Webster is supposed to be New York's best corner, but he's been proving that he's on the decline this season.
We'll be watching to see if he can bounce back against the Eagles.
Key Matchup: Eli Manning vs. Eagles Defense
There's no doubting that Manning isn't the same QB we saw win the Super Bowl MVP last season, but if he can have a good day against the Eagles, he'll have something positive to build off entering next season.
The Eagles' secondary has allowed a slew of aerial TDs, and if Manning can get back on track with his receivers, it could be an ugly day for Philly.
Manning is always the key to the G-Men's offense, which is why he's the key to this Week 17 matchup.
Prediction: Giants 20, Eagles 17
I'm still trying to decide why I'm going with the Giants, but I am.
If the G-Men actually show up, they should win this one fairly easily, but you never know.
Ahmad Bradshaw and David Wilson should be able to have their way on the ground against Philadelphia's 22nd-ranked rush defense, still giving the G-Men a shot for a playoff berth.
Follow me on Twitter: Follow @Pete_Schauer