With both of these teams playoff bound, the Houston Texans look to keep home-field advantage while the Indianapolis Colts, locked into the No. 5 seed, look to keep their momentum going into the playoffs and should get an emotional lift from the return of Chuck Pagano, who will be back coaching on the sideline.
To me, this whole game boils down to the Colts' ability to keep Andrew Luck upright. J.J. Watt was a major problem for Indy the last time around, registering three sacks and generally causing havoc down in and down out. I don't see much changing in the second meeting between these teams in 2012.
On the offensive side of the ball, Gary Kubiak has to figure out a way to attack the Colts' secondary. It's been a problem spot all year for Indy, but outside of Andre Johnson, the Texans haven't found many ways to exploit troubled secondaries.
In the video above, we look at some of the matchups and storylines surrounding this game and give our picks as to who we see winning. Let us know in the comments below where you agree, where you disagree and who you think will come out winning this Week 17 divisional showdown.