For the St. Louis Rams, a game against a tough division foe in their house will be a great way to wrap up a promising 2012 season. For the Seattle Seahawks, this will be an excellent tune-up for the playoffs.
Russell Wilson continues to make a case for Offensive Rookie of the Year, and Marshawn Lynch continues to wreck everything put in his path. On the defensive side of the ball, Gus Bradley's guys are not afraid to lay the wood on anyone and everyone, anywhere on the field.
Jeff Fisher's group is no stranger to contact, of course, and you can expect a lot of talk between plays from both of these teams.
Ultimately, the Seahawks are the better team and should win the game. They're simply too talented on both sides of the ball, and they get better quarterback play out of Russell Wilson than the Rams get out of Sam Bradford.
In the video above, we look at the biggest matchups and give our predictions for the game. Let us know in the comments below who you agree or disagree with and who you think will win the game.