Last-Minute Odds, Picks Against the Spread for NFL Week 16

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Last-Minute Odds, Picks Against the Spread for NFL Week 16
Matt Kartozian-USA TODAY Sports
Can Patrick Willis and the 'Niners defense hold off Seattle?

Folks, here go, Week 16 and last-minute NFL picks with the spread.

With postseason and NFL draft order implications on the line, we can fully expect one awesome day of football.

And it ends with a colossal NFC matchup between the San Francisco 49ers and Seattle Seahawks.

There, pro football fans get an early holiday present in two teams that are exact replicas of one another. Is there an advantage for San Francisco or Seattle despite being mirror images?

Yes, believe it or not.

But before we check out the prime-time showdown, let's view the rest Sunday's action.

 

Note: All spreads are courtesy of FootballLocks.com.

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