With a win, the 49ers would take the NFC West division title. But with a 6-0 record at home, the Seahawks look to force San Francisco into beating the Arizona Cardinals at home next week.
Both teams come into this game looking significantly different on offense. In their Week 7 meeting, Russell Wilson had improved from previous weeks, but several dropped passes plagued the offense. For San Francisco, Colin Kaepernick was still on the bench behind Alex Smith.
Seattle's defense comes into the game with the disadvantage of not having played against Kaepernick and his zone-read offense. Of course, the Seahawks defense has the fortune of practicing against their own quarterback who's also having success with it.
One big question for the Seahawks is who will be starting in their secondary come Sunday, and it might just be the key to the game on Sunday.
Statistics from Pro Football Focus unless otherwise noted.