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Hugo Lloris; Kyle Walker, William Gallas, Michael Dawson, Jan Vertonghen; Aaron Lennon, Sandro, Moussa Dembele, Gareth Bale; Emmanuel Adebayor, Jermain Defoe.
Tottenham had a defensive reshuffle after defeat to Everton, with Naughton replacing Steven Caulker, and Vertonghen switching over to centre-back.
This worked well against Swansea, although Stoke's height and obvious threat from set-pieces may well tempt Villas-Boas to bring in Dawson and revert Vertonghen to left-back.
Presuming Bale is fit enough to return, he will slot straight back in, and then it is a decision over which of Adebayor and Clint Dempsey misses out. A selection which will determine the formation.
Roared on by a home crowd, Villas-Boas is more likely to favour a 4-4-2 approach, as long as Adebayor recovers from his recent knock.
Asmir Begovic; Andy Wilkinson, Ryan Shawcross, Robert Huth, Geoff Cameron; Jon Walters, Glenn Whelan, Steven N'Zonzi, Dean Whitehead, Matthew Etherington; Peter Crouch.
Tony Pulis' side should remain largely the same as in recent weeks, although Charlie Adam's probable absence will leave a decision to be made in midfield.
Whitehead is most likely to come in, but Wilson Palacios will keen to face his previous side.
Pulis' other dilemma is whether or not to bring in Crouch for Kenwyne Jones, who finally broke his 27-game scoring duck against Everton last week.
Etherington is another hoping to face his former club, and he should stay in the side over Michael Kightly.