There is plenty of jockeying for playoff positioning to be done across the entire NFL, but head coaches must be smart when dealing with injuries to major stars in Week 16.
For teams already in the postseason, the future has to be weighed much heavier than a regular season matchup even if it has playoff implications.
Here are the four players who should stay on the sideline this weekend.
Kirk Cousins started in place of the injured Robert Griffin III in Week 15, and after a shaky start, he efficiently led the Washington Redskins to an impressive road win.
The former Michigan State star completed 26-of-37 passes for 329 yards with two touchdowns and only one interception.
Though anything is possible in the NFL, playing the hapless Philadelphia Eagles gives the Redskins the luxury to keep their star quarterback rested for one more week prior to the huge season finale against the Dallas Cowboys.
Be smart, Mike Shanahan.
This one's tough.
The 49ers travel to Seattle for what will be a battle with some NFC West title implications.
However, San Francisco can't afford to lose Smith in the long term, as he'll undoubtedly be needed at full strength for the postseason.
If Smith plays, it's not the end of the world, but don't be surprised if the 49ers err on the side of caution.
Remember, the 49ers play the Arizona Cardinals in Week 17.
Regardless of Week 16's outcome against the Seahawks, if San Fran beats the Cardinals in the season finale, they win the NFC West.
Tracy Porter has been out since Week 6 with seizure symptoms.
He has been cleared to play by doctors, and although time won't necessarily heal his ailment, he doesn't need to play against the Cleveland Browns in Week 16.
Since the cornerback was made inactive, the Broncos are 9-0.