There is no doubt that the training staffs for both the 49ers and Seahawks will be busy after this game. 

Two of the hardest-hitting teams in the league meet in Seattle in an epic NFC West matchup between teams that are somewhat mirror images of each other. You might consider the 49ers the big brother to Seattle's little brother. The little brother wants what the big brother has and won't ever get it until he figures out a way to beat his big brother. 

That's exactly what I expect to happen when Seattle hands the 49ers a big-time loss on Sunday. In the video above, Matt Miller and I differ on the outcome and pretty much everything else having to do with this game. 

We look at the biggest matchups and give our predictions for the game. Let us know in the comments below who you side with, and let us know who you think will win what is sure to be a knock-down-drag-out fight.