Rookie quarterback Russell Wilson had a phenomenal game, scoring four total touchdowns—one passing and three rushing—and combining for 297 total yards.
Marshawn Lynch added another 113 yards and a touchdown on 10 carries, and the Seahawks were up by 26 points before halftime.
C.J. Spiller had a productive outing in defeat, as he rushed for 103 yards and one touchdown on 17 carries, but Ryan Fitzpatrick struggled mightily against the vaunted Seahawks defense, and the Bills offense never had a chance to get back into the game.
Fitzpatrick finished the game with 217 yards, passing for one touchdown and two interceptions—one of which was returned by Earl Thomas for a touchdown in the third quarter, putting the Seahawks up by 30 points—and losing one fumble.