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The Ramon Sanchez Pizjuan is no easy place to go to, as Real Madrid will attest following their Week 4 trip to Sevilla.
On that day, it was Piotr Trochowski who hammered home the winner past Iker Casillas, leaving Real Madrid struggling to find a way to build on their solitary win at that point.
But the Ramon Sanchez Pizjuan proved to be a good hunting ground for Ronaldo last season, as the forward produced an outstanding performance with a hat-trick.
The context of that game was far more impressive. Only the league game prior had Ronaldo been heavily criticised for his lack of show in the Clasico against Barcelona.
Ronaldo, however, wasn't having any of it, as he rolled up his sleeves and played a leading role in the dismantling of Sevilla.
The Portuguese flyer wasn't done with that game either. The return match at the Bernabeu saw another impressive performance from Ronaldo, in which he bagged the opening goal of a 3-0 win.
The highlight of Ronaldo's clashes with Sevilla certainly came in the 2010/11 season, where another imperious performance saw the forward drive four goals past the home side in Seville, resulting in another 6-2 victory.
Sevilla were one of the more standout Spanish teams during the last decade, winning back-to-back UEFA Cups and the Copa Del Rey twice, as well as helping to raise the profile of players like Dani Alves and producing Sergio Ramos.
But on more than one occasion, Ronaldo shone brightest against one of La Liga's more impressive sides.