Though Pacquiao owns a 2-0-1 record against Marquez, controversial scoring decisions by the judges have boxing fans craving another match and hoping for a definitive answer on Saturday night.
In three matches against Pac-Man, Marquez has proven his worth as a legitimate competitor against arguably the world's best pound-for-pound fighter.
We'll find out if he has what it takes to finally overtake Pacquiao and his speedy style of fighting.
Here's your viewing information for the entire card:
Where: MGM Grand Garden Arena in Las Vegas, N.V.
When: Saturday, Dec. 8 at 9 p.m. ET
Watch: HBO PPV
Live Stream: TopRank.com
Undercard (begins at 9 p.m. ET)
Super Featherweight Bout: Yuriorkis Gamboa vs. Michael Farenas
Lightweight Bout: Miguel Vazquez vs. Mercito Gesta
Featherweight Bout: Javier Fortuna vs. Patrick Hyland
Main Event (following under-card)
Welterweight Bout: Manny Pacquiao vs. Juan Manuel Marquez
What to Watch For
We've seen some pretty close fights between these two and I don't expect anything different on Saturday night.
Look for Pacquiao to come out strong, using his speed and combinations to break Marquez down in hopes of his first knockout of the Dinamita.
For Marquez, he'll be trying to take this thing into the later rounds and use his powerful counter strikes to his advantage.
Marquez will undoubtedly put up a solid fight—as he always does—but I think Pac-Man wins this one in unanimous fashion.
Whether you agree with the scores of the past fights or not, Marquez has proven that he's not on the same level as Pacquiao.
This one goes the distance, but ultimately Pacquiao is crowned the victor.
Follow me on Twitter: Follow @Pete_Schauer