Manning passed for 242 yards (27-of-38) with three touchdowns and one interception, while Freeman threw for 242 yards (18-of-39) with two touchdowns and one interception.
Wide receiver Demaryius Thomas was Manning's go-to guy for scores, reeling in eight catches for 99 yards and two touchdowns.
Rookie running back Doug Martin was stymied by the Broncos defense most of the afternoon, managing just 56 yards on 18 carries.
Von Miller had a big game, as he tallied one sack and intercepted Freeman late in the third quarter, taking the pass back 26 yards for a touchdown.
The Broncos won their seventh game in a row and improve to 9-3 on the season. They'll travel to face the Oakland Raiders on Thursday Night Football in Week 14.
The Buccaneers fall to 6-6 and will host the Philadelphia Eagles next Sunday.