San Francisco 49ers vs. St. Louis Rams: Live Score, Highlights and Analysis

49ers lose to the Rams 16-13 in OT

The San Francisco 49ers (8-3-1) were handed their third loss of the 2012 NFL season by their division rival. The St. Louis Rams (5-6-1) played with the Niners all day long, looking great defensively for 5 quarters.

A rematch that ended in a tie in Week 10 went to overtime once more.

49ers starting QB Colin Kaepernick failed to generate offense consistently throughout the day. While he showed some glimpses of good play, two of the Rams' scores came off of Kaepernick mistakes -- including their only TD of the day.

The San Francisco loss comes at a very strange time. The team is trying to move forward into the Kaepernick era, but this performance will no doubt attract some naysayers. The Niners are title contenders, yet they cannot convincingly defeat a lackluster Rams team.

The 49ers missed an opportunity to help themselves today.

4:47 PM ET

#Legatron Greg Zuerlein and the #Rams stun the @49ers in OT. Amazing games today #sundaysarefor #NFL Football! Now onto the afternoon games
— Warren Moon Official (@WMoon1) December 2, 2012

4:47 PM ET

Also, blown safety call and copious amounts of penalties...

So many issues: Kap going out-of-bounds, Harbaugh playing for 51 y FG w/ slumping kicker, the risky play call/fumble ...
— Brian Murphy (@knbrmurph) December 2, 2012

4:45 PM ET

Then there's also just this: Legatron good from 54; Akers bad from 51. #49ers
— Brian Murphy (@knbrmurph) December 2, 2012

4:44 PM ET

Delanie Walker's game winning touchdown drop proved costly.
— Ryan Riddle (@Ryan_Riddle) December 2, 2012

4:35 PM ET

St. Louis Wins

Colin Kaepernick handed his first loss as a starter.

#Rams win. Jeff Fisher knows how to play the #49ers.
— Matt Miller (@nfldraftscout) December 2, 2012

4:34 PM ET

149 minutes, 30 seconds of Rams-#49ers football in one year is about the limit for most reasonable humans.
— Brian Murphy (@knbrmurph) December 2, 2012

4:33 PM ET

Jackson is one in short. It's 4th and inches with 1 minute left in OT.#Rams #49ers
— Christian Gin (@CGin49ers) December 2, 2012

4:31 PM ET

Jeff Fisher needs a game management coach.
— Matt Miller (@nfldraftscout) December 2, 2012

4:30 PM ET

2:00 remaining in OT...

4:29 PM ET

The Rams are going to go in for the steal

Pending some tremendous mishaps, this looks like St. Louis could emerge with the win.

Jackson runs to 49ers 37 Gain of 8.55-yarder from here but the Rams have another 2 downs for more yardage.
— Kevin Lynch (@klynch49) December 2, 2012

4:28 PM ET

Rams are now in Greg Zuerlein's range.
— Matt Barrows (@mattbarrows) December 2, 2012

4:27 PM ET

Rams with great starting field position

The 49ers No. 1 defense really needs to show up right now

David Akers is wide right from 51 yards out as the Rams take over with about 4 minutes left. #49ers
— San Francisco 49ers (@49ers) December 2, 2012

4:26 PM ET

AKERS MISSED

David Akers hooked 51-yard potential winning FG wide. Can't do that. Horrible year continues
— Cam Inman (@CamInman) December 2, 2012

4:24 PM ET

5:30 remaining in OT...

And the 49ers are in FG range, but they are continuing to plug away at the Rams defense.

4:22 PM ET

Jacobs gets 2 to the Rams' 43. Third and 3
— Kevin Lynch (@klynch49) December 2, 2012

4:21 PM ET

Hekker shanked it! A 14-yard punt.

#49ers take over at SF 49 after a punt and great 3rd down stop by @realtb25
— San Francisco 49ers (@49ers) December 2, 2012

4:20 PM ET

Another great effort by Tarell Brown

Rams look like they are short; 49ers will get another chance.
— Kevin Lynch (@klynch49) December 2, 2012

4:18 PM ET

9:28 remaining in OT...

And the Rams will get the ball back on offense, starting at their own 27-yard line. A 60-yard boot from 49ers punter Andy Lee.

4:17 PM ET

49ers Punt

#49ers will have punt.Randy Moss is short.
— Christian Gin (@CGin49ers) December 2, 2012

4:16 PM ET

Have to question the play calling here...

Gore gets 1, it's 3rd and 19
— Kevin Lynch (@klynch49) December 2, 2012

4:14 PM ET

49ers burn 2nd T.O. ... Kaepernick not looking in control of this offense.
— Cam Inman (@CamInman) December 2, 2012

4:13 PM ET

Kap had Davis open for at least 30 yards, but missed him; Kilgore called for holding
— Kevin Lynch (@klynch49) December 2, 2012

4:12 PM ET

Penalties have continued to hurt the 49ers...

It has been a major theme in this ball game, and when it all adds up, it could cost them.

4:11 PM ET

Dilip Vishwanat/Getty Images

11:49 remaining in OT...

And it's time to find out what Colin Kaepernick is made of. Does he have the Favre gene? The Brady gene? If he is able to conquer this moment, it would be a huge statement in his young career.

4:08 PM ET

Rams forced to punt, now in sudden death OT...