On paper, an away tie with the Premier League champions tends to fill most supporters with angst, but the Toffees travel to Eastlands having won an impressive eight of the previous 10 contests between the two teams.
Roberto Mancini is fully aware of his side's previous troubles against Everton, stating so in the Daily Mail:
"I think (facing) Everton is difficult for everyone, for us, for Manchester United, for Chelsea. Because every game they play against a top squad, they play very, very well. Every match we play against them, we have a problem."
"I think that tomorrow will be the same. For the top team to beat Everton, it is difficult. They always play 100 percent, and you beat them only if you play a fantastic game."
Will the Toffees maintain their remarkable record against their wealthy adversary, or will Manchester City's quality shine through?
Here are five predictions for tomorrow's clash.