With 32 points on the season, Man City sits in second place in the table, trailing first place Manchester United by only one point. Everton, currently in sixth place with 22 points, finds themselves within striking distance of a top four spot in the table, four points behind fourth place West Brom.
Both squads last played on Wednesday, with City defeating 15th place Wiggan Athletic 2-0 while Everton battled third place Chelsea to a 1-1 draw.
Football fans from around the globe will be tuning in to see how this one plays out. Let's take a look at the viewing information for Saturday's EPL showdown and preview the action.
Where: Ethiad Stadium in East Manchester, England
When: Saturday, December 1 at 10 a.m. ET
Watch: Fox Soccer
Live Stream: Fox Soccer 2Go
How will this one end?
The all-time series between these two EPL foes is virtually even: Manchester City have won 59, Everton 60, with 39 draws. However, Everton has won eight of their past 10 meetings.
With an epic battle on the horizon against Manchester United next weekend, City must be careful not to look ahead and focus on the task at hand with Everton.
They'll be playing without one of their two goal scorers from their victory against Wiggan, as James Milner is out of this one due to a hamstring injury, according to the official Twitter account of the Manchester Evening News:
James Milner out, Samir Nasri back for Manchester City dlvr.it/2YnSYm
— Manchester City News (@ManCityMEN) November 30, 2012
Everton is bolstered by the return of their excellent midfielder Darron Gibson, who logged 73 minutes of action against Chelsea on Wednesday, but the injury news isn't all good.
Leighton Baines, who has created more chances for his teammates (53) than any other player in the Premier League, injured his hamstring against Arsenal and his status—as well as that of striker Nikica Jelavic—for Saturday's showdown is in doubt, according to manager David Moyes (h/t The Daily Mail):
Leighton's got a hamstring injury. He felt it in the game and played on in the last 10 or 15 minutes.
I felt we put in a lot of energy (in the game) but it might take its toll.
We've got Gibbo (Darron Gibson) and Hibbo (Tony Hibbert) back and that has eased it a little bit but I am worried about Nikica Jelavic (ill) who has not trained since Saturday and on Tuesday I was not playing him.
While Everton has gotten the best of City lately, the home team has yet to drop a point at the Ethiad this season. Everton's task to best City would be difficult with a healthy Baines and Jelavic, but without them, it's going to be incredibly difficult for the Blues to emerge with a point in this one.
Prediction: Manchester City 3, Everton 1