Their three previous meetings have been razor close, with Pacquiao holding a 2-0-1 record, and you could easily argue for either man winning all or none of the fights.
Regardless of the outcome Saturday night, fans will certainly be clamoring for the Pac-Man to seek out new challenges in the coming year.
And lucky for us there are plenty of them out there. Even a few that don't include a certain fighter whom we have been hoping to see Pacquiao face for seemingly forever now.
It's worth noting that the continuing feud between Golden Boy Promotions and Top Rank, which promotes Pacquiao, is likely to continue to prevent big fights.
Several of these include Pacquiao.
Join us as we breakdown everything from the likely to the pipe dreams, five potential future opponents for the Pac-Man.