The Brendan Rodgers men will want to return to winning ways as soon as possible, but the in-form Southampton side, unbeaten in their last four outings, will be a tough nut to crack.
What can we expect from this match?
Continue reading and find out.
Luis Suarez's incredible goal-scoring form will continue against Southampton as he will net his second hat-trick of the season.
Having already conceded 31 goals this season, the Saints have the worst defensive record in the Premier League.
Couple Southampton's inability to defend and Suarez's prowess in front of goal and this game is bound to be an entertaining, high-scoring encounter.
The Uruguayan will seemingly continue to dominate Premier League's goal-scoring charts for quite some time.
Suarez is currently just one yellow card away from suspension.
Although he'll probably enjoy playing against Southampton, the Uruguayan will be shown a needless yellow card in the second half and will thereby be suspended from Liverpool's next match.
Suarez might be a fantastic forward, but he needs to learn how to behave himself during the match.
The Saints might have a disastrous defensive record, but they have already shown that they more than capable to cause problems to opposing teams.
This might come as a shock to you, but Southampton actually scored more goals than Liverpool this season.
Rickie Lambert tops the goal-scoring charts in Southampton with six goals to his name, and, similarly to Suarez, he will cause plenty of problems and eventually get on the score sheet.
Despite his fantastic performances in Europa League, Oussama Assaidi still hasn't started a Premier League match this season.
Assaidi's last display in Premier League came during the midweek match against Tottenham as he replaced Stewart Downing in the 64th minute. The Moroccan was far from inspirational, but his performance was a decent one, nonetheless.
Assaidi will finally get his chance and he will start a Premier League match for the first time in his career.
Gaston Ramirez had been continually linked (via Daily Mail) to Liverpool before he joined Southampton. However, the Reds surprisingly gave up their pursuit and the Saints were quick to sign him up.
The Uruguayan has been the Saints' stand-out performer so far, and he will have plenty of desire and determination to perform well against the Reds.
This will be Ramirez's first encounter with Liverpool and he will make Brendan Rodgers regret not signing him when he had the opportunity.
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