As the NFL transitions more and more into a quarterbacks league, the need for an elite signal-caller is a must in today's game.
It's always more comfortable for players heading into a week knowing they have the support of the crowd, and playing at home this week, I'm expecting big things out of these stud QBs in Week 13.
And no, New York Jets fans, Mark Sanchez is not on this list.
Manning gets himself a Tampa Bay Buccaneers defense that ranks dead-last against the pass, surrendering an average of more than 315 aerial YPG, much to the liking of Mr. Manning.
The 36-year-old veteran ranks No. 3 among NFL QBs in passer rating (104.8), touchdowns (26) and completion percentage (67.7) and will see a Bucs defense that has allowed 18 passing touchdowns, which ranks in the lower half of the league.
With Manning and the Broncos' offense rolling of late, there's no reason to think he won't go out there and handle his business at Mile High.
Robert Griffin III
While I do think the New York Giants will beat the Washington Redskins, I'm expecting another big day from RGIII—eight touchdowns in the past two games will do that to you.
New York's secondary has been susceptible to big plays in the secondary—as we saw the first time these teams met in Week 7—and with Pierre Garcon back in the mix for the Redskins, RGIII has another weapon at his disposal.
The rookie QB threw for 258 yards and two touchdowns and rushed for 89 yards on the road against the G-Men in their first meeting and playing at home Monday night, I like his chances for another big game at FedEx Field.
Thursday Night Football will see two of the best quarterbacks the NFL has to offer when Drew Brees and the New Orleans Saints travel to the Georgia Dome to face Matt Ryan and the Atlanta Falcons.
If you read my preview, you know who I went with in this one. And if you didn't, well, I'm sure you've figured it out by now.
Ryan loves playing at home and has a favorable matchup against a weak Saints secondary that Ryan tore apart in Week 10, tossing for 411 yards and three touchdowns. I don't like this matchup. I love it.
After a dismal performance against the Super Bowl champs, Aaron Rodgers should have a bounce-back week, especially with Greg Jennings returning to action (h/t ESPN).
Granted, the Minnesota Vikings have a good defense, but I can't see Rodgers having a bad game two weeks in a row.
He's got too many weapons in Jennings, Randall Cobb, Jordy Nelson and James Jones not to have a successful day at Lambeau Field.
Follow me on Twitter: Follow @Pete_Schauer